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CosMedix Refine .5 oz

Item # 8555207
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CosMedix Refine .5 oz
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Cosmedix Refine 4% .5 oz.

Cosmedix Refine 4% is a trans-retinol serum as potent as Retinoic Acid. It is chirally corrected to reduce irritation and photo sensitivity with increased effectiveness. Improves skin's texture, firmness and smoothness. Essential for the function and generation of skin cells and collagen/elastin production. Helps break up hyper pigmentation. Comparable to .05 Retinoic Acid. By purifying Vitamin A to its most natural and active state, Refine 4% is more readily absorbed and utilized by the skin than other products. This potent, chirally corrected L-retinol A formula restores life to environmentally damaged skin by stimulating cell turnover and collagen production in a non-drying formula fortified with essential oils. Hydrates and erases fine lines without inflammation for noticeably improved skin texture. A night time anti-aging miracle!


  • Increases cellular turnover Less irritation/redness than with other retinoids
  • Stimulates collagen/elastin/GAG production
  • Reduces fine lines/signs of aging
  • Improves skin texture and color
  • Anti-acne/anti-bacterial/anti-sebum

Indications: For acne Blemished skin Hyperpigmentation/melasma Sun damaged/stressed skin (face and body) Fine lines and wrinkles Enlarged/clogged pores.


  • Apply a pea-sized amount to clean skin every other evening until tolerance allows for nightly use.
  • Do NOT apply to eyelids!
  • Discontinue use if redness or irritation occurs; resume at a lower dosage after discomfort has subsided.
  • May experience mild peeling.
  • Use caution when applying to neck and chest area.


Aqua (Water), Hamamelis Virginiana (Witch Hazel) Water, Retinol, Cassia Angustifolia Seed Polysaccharide, Glycerin, Sodium Lactate, Proline (L), Sodium PCA, Sodium Hyaluronate (L), Squalane, Dimethicone Copolyol, Helianthus Annuus (Sunflower) Seed Oil, Galactoarabinan, Xanthan Gum, Benzyl Alcohol, D-glucuronic Acid, Santalum Album (Sandalwood) Oil, Jasminum Officinale (Jasminum) Extract, Citrus Aurantium Bergamia (Bergamot) Fruit Oi

Product Reviews (2 Reviews)

  • 5
    Works SO Quickly!

    Posted by Jenna on 3rd Oct 2016

    I just gave this product to my mother and she's only been using it about 3 days. I'm astounded by the difference in her skin already. Her skin glows more and her deep and and fine lines are already greatly diminished. Fantastic product!!

  • 5
    One of my favorite skin care products. Once this bottle is done I'm moving up to the Plus.

    Posted by Pat on 29th Apr 2015

    One of my favorite skin care products. Once this bottle is done I'm moving up to the Plus.

Customer Testimonials