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Use every 2 to 4 weeks. Pre-moisten face with water then apply a thin even layer, gently rubbing in a circular motion. Leave on for up to 5 minutes and allow enzymes to function. Rinse with water and immediately pat dry. Temporary post treatment redness may occur for a period of up to 30 minutes due to increased circulation. If excessive irritation or sensitivity continues, discontinue use. For best results follow your Innovative Skincare regime.